Can CBD Oil Be Taken With Any Other Medications

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Can CBD Oil Be Taken With Any Other Medications

CBD can be taken along with other medicines such vitamins but some medicines may have negative effect when used in combination with CBD.

The interaction of some medicines with CBD is given below:

CBD and Vitamins: It is not only healthy for you, but the CBD Oil may allow some of your natural supplements to function better. In conjunction with a proper balanced diet and exercise, the potentials of CBD Oil and other supplements are almost limitless. Yes, CBD Oil is actually considered a dietary supplement.

CBD and blood pressure medicines: CBD can potentially inhibit the activity of the liver enzyme called cytochrome P450. In particular, CBD can regulate blood pressure effectively enough to warrant reduction in HBP medications. To put this in perspective, though, eating a portion of grapefruit would have a similar effect on the P450 liver enzymes.

CBD and Antibiotics: Because of the way the body metabolizes CBD, it is possible that it could interact with some medications, including some antibiotics.


CBD and antidepressants: CBD has the potential to interact with SSRIs, and other antidepressants, resulting in increased amounts of antidepressant in the body and a higher risk of side effects.

CBD and blood-thinning medicines: Interaction Between CBD and Drugs that Increase Risk of Bleeding. Studies have shown that CBD and other plant cannabinoids can increase the effects of drugs used for blood-thinning (e.g. warfarin) or drugs with a risk of blood-thinning.

CBD and chemical CYP450

Any drug metabolized by CYP450 enzymes could interact with cannabidiol. According to the Medical Dept, Indiana University, drugs known to use the CYP450 system are:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas


This list does not include all of the potential medications impacted by cannabidiol. Nor will every medication in the categories contained on this list will cause an interaction. For these reasons, you should consult with a medical professional before supplementing with CBD oil.

There are certain medications, known as “prodrugs,” that need to be metabolized to produce the therapeutic compound. In other words, you ingest an inactive compound and once in the body, it is processed into the active drug. If this processing is dependent on CYP3A4 (part of the larger CYP450 system), then inhibitors can result in too little active drug in the body for the desired therapeutic effect.

Codeine, for example, is a prodrug that is metabolized into morphine which provides the effect.

Vyvanse and Concerta are two other popular pharmaceutical medications for ADHD that fall into this category.

If you are worried that your CYP450 pathway may not be functioning properly, physicians can test the system to ensure that the medications you take are metabolizing as expected.


Alcohol and CBD Oil

Alcohol and cannabis are both extensively consumed in our society and the effects of combining the two are well known.

What are less understood by the general public, is the effects of combining alcohol and the cannabinoids compound CBD.

Alcohol depends on a few different metabolic pathways in the human body, with the primary enzymes involved being:

  • Alcohol dehydrogenase (ADH)
  • Aldehyde dehydrogenase (ALDH)
  • CYP450 (specifically CYP2E1)

In people who only drink socially or occasionally, ADH and ALDH handle the entire workload of metabolizing ethanol. However, when binge drinking (or during chronic consumption of alcohol) CYP450 gets involved to assist the overloaded ADH and ALDH pathways.

Here are some interesting facts about alcohol and CBD oil:

  • The CB1 receptor is a significant player in the reinforcing and motivating attributes of alcohol.
  • Combining alcohol and CBD results in significantly lower blood levels of alcohol.
  • CBD reduces the reinforcement, motivation and relapse for alcohol.
  • CBD protects the liver from damage done by binge-drinking alcohol.
  • CBD prevents against alcohol-induced neurodegeneration.
  • CBD attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil mediated injury.
  • Cannabinoids have an effect on nearly all enzymes responsible for metabolizing alcohol.
  • CB1 receptor agonists (THC) encourage alcohol consumption, while CB1 receptor antagonists (CBD) decrease it. 



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